The Corrections Department announced Wednesday that Sandusky was transferred to Greene State Prison after being evaluated at a facility outside Harrisburg.
Prison officials say he'll be placed in protective custody because of the nature of his crimes and his high profile.
The 68-year-old Sandusky was convicted this summer of 45 criminal counts for the sexual abuse of 10 boys over 15 years. He maintains his innocence and is pursuing appeals.
He's serving a 30- to 60-year sentence that means he's likely to die in prison.