Manning’s yardage total was the second most for a Giants quarterback, and tied for the eighth highest in NFL history.
He threw three first-half interceptions, and came back with a monster 295 yards passing in the second, finishing 3 yards short of Phil Simms’ team record.
The Bucs (1-1) led by 11 points before the Super Bowl champions came back and avoided an 0-2 start.
CARDINALS 20, PATRIOTS 18
FOXBOROUGH, Mass. — Backup quarterback Kevin Kolb threw for one touchdown and ran for another, Stephen Gostkowski missed a potential winning field goal in the final seconds, and Arizona moved to 2-0.
The Patriots took over when Vince Wilfork recovered a fumble at the Cardinals 30 with 1:01 left.
A 30-yard run into the end zone by Danny Woodhead was nullified by a holding penalty against Rob Gronkowski. New England then moved to the 24 with 6 seconds left, but Gostkowski sent a 42-yard try wide to the left after hitting four earlier field goals.
PANTHERS 35, SAINTS 27
CHARLOTTE, N.C. — Cam Newton threw for 253 yards and ran for a career-high 71 yards to hand New Orleans its first 0-2 start since 2007.
One week after tying a franchise low with 10 yards rushing in a loss to Tampa Bay, the Panthers ran for 219 yards.
Newton, DeAngelo Williams and Mike Tolbert all scored on short touchdown runs.
Steve Smith overcame a sore knee to finish with 104 yards receiving — the 39th 100-yard receiving game of his career — and Jonathan Stewart hauled in a 17-yard touchdown reception for the Panthers (1-1).
EAGLES 24, RAVENS 23
PHILADELPHIA — Michael Vick scored on a 1-yard TD run with 1:55 left, helping Philadelphia overcome a slew of turnovers.
Rookie kicker Justin Tucker made field goals of 56, 51 and 48 yards for the Ravens, but Joe Flacco couldn’t get Baltimore (1-1) in his range in the final minute.
Flacco overthrew Ray Rice on fourth-and-1 from the Ravens 46, and the Eagles ran out the clock.
COLTS 23, VIKINGS 20
INDIANAPOLIS — Adam Vinatieri made a 53-yard field goal with 8 seconds left to give Andrew Luck his first NFL victory.
Minnesota (1-1) rallied from a two-touchdown deficit in the final 5½ minutes and tied the score on a 6-yard TD pass from Christian Ponder to Kyle Rudolph with 31 seconds left.
But that was too much time for Luck, who had thrown for two touchdowns.
He started with back-to-back 20-yard completions, then drew the Vikings offside before spiking the ball with 12 seconds to go. Vinatieri, the best clutch kicker in NFL history, knocked the 53-yarder through the uprights to win it.
DOLPHINS 35, RAIDERS 13
MIAMI — Reggie Bush ran for 172 yards and two touchdowns, and Miami won a home opener for the first time since 2005.
Ryan Tannehill threw his first NFL touchdown pass, ran for another and avoided any turnovers after tossing three interceptions in his pro debut a week earlier.
The Dolphins improved to 1-1, and Joe Philbin earned a sideline drenching for his first victory as a head coach.
The Raiders, under new coach Dennis Allen, are 0-2 for the first time since 2007.
TEXANS 27, JAGUARS 7
JACKSONVILLE, Fla. — Arian Foster ran for 110 yards and a touchdown, Ben Tate added 74 yards and two scores and Houston dominated from the start.
The Texans improved to 2-0 for the third consecutive season by winning their fourth in a row against the AFC South rival Jaguars, who started 0-2 for the third time in the last five years.
The Jaguars finished with a franchise-low 117 yards.
BILLS 35, CHIEFS 17
ORCHARD PARK, N.Y. — C.J. Spiller scored twice and had 123 yards rushing in sparking Buffalo.
Ryan Fitzpatrick threw two touchdown passes, including a 49-yarder to Stevie Johnson, and Leodis McKelvin scored on an 88-yard punt return — the second longest in team history — in the Bills’ home opener.
Buffalo’s high-priced defense had five sacks and forced three turnovers as the Bills bounced back from a season-opening 48-28 loss to the Jets last week.
Dwayne Bowe scored both touchdowns for Kansas City to make the score respectable.
BENGALS 34, BROWNS 27
CINCINNATI — Adam “Pacman” Jones returned Cleveland’s first punt 81 yards for a touchdown, and Andy Dalton matched his career high with three touchdown passes.
The Bengals (1-1) have won 13 of the last 16 against the Browns (0-2), who got impressive games from their rookie quarterback and running back but still couldn’t get a win.
STEELERS 27, JETS 10
PITTSBURGH — Ben Roethlisberger passed for 275 yards and two touchdowns and Pittsburgh smothered the Jets in the second half.
Roethlisberger completed 24 of 31 passes. He hit Heath Miller for a 1-yard score to give the Steelers (1-1) the lead late in the first half, then found Mike Wallace for a 37-yard strike early in the third quarter to break the game open.
RAMS 31, REDSKINS 28
ST. LOUIS — Sam Bradford threw for 310 yards and three touchdowns and Danny Amendola caught 15 passes for 160 yards in rallying St. Louis
The Rams made their comeback after running back Steven Jackson left the game after drawing an unsportsmanlike conduct penalty in the second quarter. Later, coach Jeff Fisher said Jackson left because of a groin injury.
Griffin ran for two touchdowns and passed for a third for Washington (1-1).
SEAHAWKS 27, COWBOYS 7
SEATTLE — Marshawn Lynch ran for 122 yards and a 3-yard touchdown in the fourth quarter and Seattle’s special teams came up with two huge first-quarter plays that led to 10 points.
Rookie Russell Wilson threw for 151 yards and directed a 90-yard scoring drive in the third quarter capped by a 22-yard touchdown strike to Anthony McCoy to give Seattle a 20-7 lead.
CHARGERS 38, TITANS 10
SAN DIEGO — Tight end Dante Rosario had three touchdown catches for the first time in his NFL career and San Diego’s defense harassed Jake Locker all day.
Before the game, the Chargers (2-0) retired Junior Seau’s No. 55. Seau, the hard-hitting, first-pumping leader of the Chargers for 13 seasons, committed suicide May 2.
Rivers was 24 of 32 for 284 yards. Malcom Floyd had six catches for 109 yards.
and Rosario four catches for 48 yards.
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