Chris Thompson ran for 104 yards and two scores and James Wilder Jr. added two touchdowns runs for the Seminoles, who broke open a close game with 35 second-half points.
Florida State (4-0. 2-0 Atlantic Coast Conference) trailed until late in the third quarter, taking its first lead at 35-31 on Manuel’s 29-yard touchdown pass to Rodney Smith. The Seminoles, who finished with 667 yards, built a 49-31 lead before Clemson scored late.
Clemson (3-1, 0-1) built a 28-14 lead early in the third quarter on a 52-yard pass from Sammy Watkins to Andre Ellington.
Virginia Tech 37, Bowling Green 0
BLACKSBURG, Va. — Logan Thomas helped Virginia Tech find its running game and the defense showed up, too, as the Hokies bounced back from a humbling loss a week ago with a 37-0 victory against Bowling Green.
Thomas, who had been reluctant to run in the first three games, had key runs on three consecutive drives in the second quarter. Each ended with a touchdown as the Hokies (3-1) built a 21-0 lead.
The Falcons (1-3) managed just 71 yards in the first half, switched quarterbacks midway through the third quarter and turned the ball over on downs three times in Hokies territory in the second half.
No. 8 West Virginia 31, Maryland 21
MORGANTOWN, W.Va. — Geno Smith threw three touchdown passes to Tavon Austin and No. 8 West Virginia outlasted Maryland 31-21 on Saturday.
Doug Rigg returned a fumble 51 yards for West Virginia (3-0) and Austin had another remarkable game against his home-state Terrapins. The Baltimore native caught 13 passes for 179 yards and set a school record for career receptions.
But West Virginia looked flat at times on offense, after averaging 56 points and 612 yards in its first two games. Smith had as many incompletions in the first half (nine) as he did in the first two games combined. He finished 30 of 43 for 338 yards.
No. 17 TCU 27, Virginia 7
FORT WORTH, Texas — Brandon Carter had a 68-yard touchdown on one of his one-handed catches, linebacker Kenny Cain recovered a fumble along with two interceptions and 17th-ranked TCU beat Virginia 27-7 Saturday for its 11th consecutive victory.
Casey Pachall threw for 305 yards and three touchdowns for the Horned Frogs (3-0), whose winning streak is the longest among FBS schools.
Josh Boyce had his TCU-record 18th touchdown catch. Freshman Jaden Oberkrom had field goals of 46 and 47 yards, the second field goal set up by Cain’s 40-yard interception return.
Wake Forest 49, Army 37
WINSTON-SALEM, N.C. — Michael Campanaro scored a career-best three touchdowns, and Wake Forest’s defense came up with a key fourth-quarter stop to beat Army 49-37 on Saturday.
Josh Harris ran for 129 yards and two touchdowns, Deandre Martin had 115 yards and two scores, and Tanner Price threw for 221 yards and two TDs for the Demon Deacons (3-1, 1-1 Atlantic Coast Conference), whose 517 total yards was their biggest offensive game since accumulating 562 against North Carolina in 2003.
Duke 38, Memphis 14
DURHAM, N.C. — Sean Renfree threw for 314 yards and four touchdowns to lead Duke past Memphis 38-14 on Saturday night.
Renfree was 26 of 37 with TDs covering 37 and 31 yards to Conner Vernon, 16 yards to Desmond Scott and 8 yards to Brandon Connette for the Blue Devils (3-1), who outgained the Tigers 500-152 and are off to their best start since 2008.
Connette also had a 4-yard touchdown run for Duke, which had four turnovers — two in the red zone, a third returned for a touchdown — but held Memphis (0-4) to less than 100 total yards until late in the third quarter.
NC State 52, The Citadel 14
RALEIGH, N.C. — Playing in his first career game, North Carolina State freshman Shadrach Thornton ran for 145 yards and two touchdowns in the Wolfpack’s convincing 52-14 win over The Citadel on Saturday night.
The Wolfpack (3-1) scored touchdowns on five of its six drives in the first half to build a commanding 35-point halftime lead.
N.C. State quarterback Mike Glennon ran for two touchdowns and passed for one more.
The senior completed 19 of 24 passes for 233 yards to lead N.C. State to its third straight victory after its season-opening loss to Tennessee.
Rashard Smith had a 73-yard punt return for a touchdown for the Wolfpack.
Cornerback David Amerson picked off Bulldog quarterback Aaron Miller for his third interception in as many games as N.C. State had its way with The Citadel (3-1).
North Carolina 27, East Carolina 6
CHAPEL HILL, N.C. — Gio Bernard scored two touchdowns in his return from a knee injury and North Carolina took over after halftime to beat East Carolina 27-6 on Saturday.
Bernard had missed two straight games since hurting his left knee in the season-opening win against Elon, but he returned with a 14-yard scoring catch from Bryn Renner in the first quarter and added a 4-yard TD run in the third.
Bernard didn’t have a big rushing day for the Tar Heels (2-2), finishing with 50 yards on 18 carries. But Renner had little trouble through the air, completing 27 of 43 passes for 321 yards and two touchdowns, including a 62-yard scoring pass to sophomore receiver Sean Tapley early in the third.
The Pirates (2-2) struggled to sustain drives all afternoon, twice settling for first-half field goals after stalling inside the 10-yard line and finishing with 233 total yards.